Six people died on the spot after a severe collision between a speeding car and a trailer on the National Highway near Noshero Feroze city of Sindh, sources said on Monday.
The car was travelling from Larkana to Karachi at the time of the accident.
Preliminary information indicates that all the deceased belonged to the Solangi community.
The crash was so strong that the car was completely destroyed in the accident.
Area residents immediately began rescue efforts after the accident and alerted relevant authorities.
Rescue teams later recovered the bodies and transported them to a hospital in Noshero Feroze.
Hospital sources confirmed that all victims were brought in dead.
Traffic on the National Highway was briefly disrupted following the accident, but was restored.
Police have taken the trailer into custody and have begun questioning the driver.
Officials said that excessive speed is being considered a likely factor behind the crash, but the final cause will be confirmed once investigations are over.