Later, Pakistani bowlers reduced Tasmania to 132 runs for six wickets, as the local side is still trailing by 305 runs.
After Salman Butt's solid 153 on Saturday, Akmal increased the pace with 109 off 81 balls as the tourists reached 437 in their first innings.
He was the last man out after hitting three sixes and 17 fours.
The Pakistanis resumed at 270 for four but Umar Akmal (27) and Fawad Alam (33) could only make starts and the best of the bottom four was Umar Gul's five.
Off-spinner Jason Krejza took three for 162 off 28.4 overs.
The Pakistani bowlers enjoyed the conditions with the ball, with Mohammad Aamer striking two early blows in his spell, and when Abdur Rauf chipped in with two of his own Tasmania were 45 for four.
George Bailey steadied things with 50 before being lbw to Saeed Ajmal (two for 56), who had already picked up Tim Paine for 16.
Aamer finished with two for 18 off 10 overs while Rauf had two for 21 off 12 as they made life hard for the locals.
The three-day game, which finishes on Monday, has been a strong hit-out for the tourists ahead of the opening Test against Australia in Melbourne on Boxing Day.