His knock was one more than former captain Mark Taylor's epic 334 against Pakistan in 1998 and the second best score by an Australian of all time after Matthew Hayden's 380 against Zimbabwe in 2003.

Matthew Wade also remained unbeaten on 38.

Pakistan did have some success. After removing Marnus Labuschagne for 162 in the opening session, they also bagged Smith, caught behind by Mohammad Rizwan off Shaheen Afridi for 36.

In making his runs, Smith -- who had a rare failure in the first of the two-Test series at Brisbane -- shattered a record that had stood since 1946.

The home team resumed the day-night second Test at 302 for one with Warner on 166 and Labuschagne 126, with the pair putting on another 67 runs before Pakistan finally got a breakthrough.

Skipper Azhar Ali took the new ball and Afridi clean-bowled Labuschagne as he attempted a drive, just as he and Warner appeared set for another long day at the crease.

The 25-year-old, who has come of age during the series, trudged back to the pavilion to a standing ovation after a classy 162, his second century in a row.

Their marathon 361-run partnership was a record second-wicket stand for Australia against Pakistan and the highest ever in a pink-ball Test.

Just minutes later, the explosive Warner completed only the second Test double century of his career. Playing in his 81st Test, he reached 200 off 260 balls with a single from Afridi, having clattered 23 fours along the way.

Pakistan thought they finally had Warner out on 226 when he was caught in the gully off debutant Musa, only for their heads to drop when it was called a no-ball.

He made them pay, passing his previous highest Test score of 253, set in Perth in 2015, before reaching his 300 off 389 balls.

Smith, Australia's saviour during the recent Ashes series against England, where Warner struggled, built a solid 36 before catching a thin edge on a big swing, with Rizwan taking a catch behind the wicket.

Pakistan have lost 13 consecutive Tests in Australia. —AFP