The House has passed a $1 trillion-plus catchall budget bill paying for day-to-day budgets of 10 Cabinet departments and averting a government shutdown.
The 296-121 vote to approve the measure represented a rare moment of bipartisanship in a polarized Capitol. Lawmakers are also seeking compromise on separate legislation to renew jobless benefits and a cut in payroll taxes.
The vote sends the measure to the Senate, which was expected to pass it on Saturday.
The bill puts in place budget curbs mandated under an August pact between President Barack Obama and Congress. It trims spending for most domestic agencies and awards the Pentagon the smallest budget hike in recent memory. It pays for overseas military operations and a slew of programs ranging from border security to flood control to combating AIDS and famine in Africa.
Many provisions sought by House Republicans were dropped from the bill before its passage, and Democrats blocked a series of GOP assaults on Environmental Protection Agency regulations, though the agency's budget absorbed a cut of more than 3 percent.
GOP leaders did succeed in halting new rules requiring energy efficient light bulbs, delays in regulations of coal dust and eliminating federal funding of needle exchange programs.