The bus was on the way to Karachi from Manshera but it lost the control due to over speeding at Hatri bypass, which killed five people on the spot and injured many others including women and children.
The deceased include two men, two women and two children.The injured were shifted to the Civil hospital Hyderabad and three of them got serious wounds, doctors said.
Edhi ambulances reached the spot for rescue work. However, the driver and conductor of the bus managed to flee after the accident.
According to the passengers the accident happened due to rush driving and continuous use of mobile phone of the driver.
On Monday, two tragic accidents occurred near Kahuta, which killed 32 people and injured various others.