Shahid Khan Afridi scored 28 and Steven Finn took four wickets as Pakistan were bowled out for 130.
Earlier England set Pakistan a target of 261 to clinch the first one day international in Abu Dhabi.
Alastair Cook top-scored for England with 137 as the tourists made 260-7 after winning the toss. Saeed Ajmal with 5-43 was Pakistan's most impressive bowler.