The latest instalment, which will be titled A Good Day To Die Hard, will centre around the action man - played by Bruce - and his son as they get involved in a prison escape.
"Since the first Die Hard in 1988, John McClane has found himself in the wrong place at the wrong time, with the skills and attitude to always be the last man standing, making him enemy number one for terrorists the world over," 20th Century Fox revealed in a statement.
"Now, McClane faces his greatest challenge ever, this time on an international stage, when his estranged son Jack is caught up in the daring prison escape of a rogue Russian leader, and father and son McClane must work together to keep each other alive and keep the world safe for democracy."
Directed by Max Payne's John Moore, filming on Die Hard 5 is due to begin in Russia in January 2012, for a planned 2013 release.