O'Driscoll missed this month's loss to Scotland and last weekend's 19-12 loss to France in Bordeaux. He's in a run-on side with 10 changes, six of them in the backlinhe halves are Jonathan Sexton and Tomas O'Leary.
Flanker David Wallace makes his first appearance this month, and lock Paul O'Connell and No. 8 Jamie Heaslip will start after coming off the bench in Bordeaux.