The group, which deals with strengthening Pakistan's law enforcement agencies in counter-terrorism, had earlier met in Washington last October where the two sides had agreed to take steps to enhance cooperation.
US Assistant Secretary of State for International Narcotics and Law Enforcement William Brownfield and Pakistan's Interior Secretary Khawaja Siddique will lead their respective sides at the talks.
"The talks will focus on cooperation between the law enforcement agencies of the two countries," The secretary foreign office Tehmina Janjoa quoted while talking to AAj news.
The US is providing training to police and other law enforcement agencies to effectively deal with terrorism.
However, the cooperation between the two sides has been affected following the secret US military operation to kill Al-Qaeda chief Osama bin Laden in Abbottabad last month.