According to details, the unmanned predator plane fired four missiles at compound and a vehicle in two different attacks in Bangi Darra area in Ghulam Khan tehsil in Miranshah, the main town of North Waziristan.
Four missiles were fired at a vehicle and a compound, killing at least 20 people. The vehicle and compound was destroyed in the attack.
The local intelligence official and another security official in Peshawar confirmed the drone attack and toll.
It was not immediately clear if the drones were chasing any high value target.
A covert US drone campaign in Pakistan has stepped up strikes in the tribal areas of Khyber Pakhtunkhawa.