Joss Whedon's The Avengers has set a new bar in opening to a walloping $200.3 million at the domestic box office, the largest debut ever and kicking off summer 2012 in high style.

The 3D tentpole -- marking a major victory for Disney and Marvel Studios -- easily dethroned Harry Potter and the Deathly Hallows: Part 2, which opened to $169.2 million last summer, then the largest number in history.

Avengers opened a week ago overseas, earning a whopping $441.5 million through Sunday. The pic's worldwide total of $641.8 million has already surpassed the lifetime totals of Captain America: The First Avenger ($364 million), Thor ($449 million), Iron Man ($585 million) and Iron Man 2 ($624 million).

Avengers is now positioned to reach $1 billion in global grosses in a much-needed win for Disney, which posted a $200 million loss after John Carter cratered at the box office earlier this year. It's also a validation of Marvel's strategy to build a franchise by turning out single titles -- Iron Man, Thorand Captain America -- and then bring the characters together. Avengers also could reboot The Hulkfilm franchise.

Among other records, Avengers is the first film in history to cross $200 million in only three days of play at the domestic box office. It also scored the biggest Saturday gross of all time in earning $69.7 million.

"It's been a fantastic weekend on every single front," Disney executive vice president of distribution Dave Hollis said.

Hollis said the slim 13 percent drop from Friday to Saturday reflects great word of mouth, as well as the fact that all segments of the audience are turning out, including families. Roughly 52 percent saw it in 3D.

The tentpole played evenly in terms of age, with 50 percent of the audience under the the age of 25 and 50 percent over. Couples made up 55 percent, families 24 percent and teens 21 percent. Males represented 60 percent of the audience.

IMAX theaters reported record business, generating north of $15 million in ticket sales domestically to tie with Deathly Hallows Part 2 for the biggest opening weekend in the circuit's history. IMAX expects to finish the weekend with a worldwide cume of $31.2 million.

Avengers is the first Marvel title marketed and distributed by Disney since buying Marvel. Paramount distributed Marvel's previous films and, in exchange for ending its output deal early with Marvel, will receive a mininum of  $115 million in distribution fees for Avengers and next summer'sIron Man 3.

Avengers was the only wide release of the weekend. At the specialty box office, Fox Searchlight looked to counterprogram with The Best Exotic Marigold Hotel, which opened in 27 theaters in 12 markets. Marigold grossed $750,301 for a pleasing per location average of $27,789.

Fox Searchlight's Sheila DeLoach said the film -- which has already a stellar $72 million overseas -- succeeded in luring baby boomers, evidenced by sold out matinee and early evening shows. Marigold stars Judi Dench, Bill Nighy and Tom Wilkinson.