A day after killing Iran’s powerful security chief Ali Larijani in the ‌highest-level assassination since the supreme leader died on the war’s first day, Israel said it had killed another top official, Intelligence Minister Esmail Khatib.

Iran confirmed the death of Larijani and retaliated by firing missiles with multiple warheads into Israel that Israeli authorities said killed two people near Tel Aviv.

Tehran said the killing of officials would not hinder its operations.

Foreign Minister Abbas Araqchi said the United States and Israel failed to understand that the Islamic Republic was a robust political system that did not depend ​on any single individual.

Nearly three weeks into the conflict, there are scant signs of de-escalation.

An unprecedented disruption to global energy supplies has raised the political stakes for US President Donald Trump.

Diesel ​prices in the United States rose above $5 a gallon on Wednesday for the first time since the 2022 inflation surge that eroded support for his predecessor ⁠Joe Biden.

Israel has stepped up its strikes on Lebanon and a ground assault in the south in pursuit of the Iran-backed Hezbollah group, which has fired across the border in solidarity with Tehran.

Worst strikes in decades

In central Beirut’s Bachoura district, Israel warned residents to leave a building it alleged was used by Hezbollah, which it then completely flattened.

Eyewitness video, verified by Reuters, showed the structure crumbling into dust as it was struck at dawn.

Firefighters later clambered over a vast pile of smoking rubble.

Abu Khalil, who lives in the area, said he had helped people flee nearby homes early that morning after the Israeli warning.

“It’s just an operation to hurt, to ​terrify people, to terrify children,” he told Reuters, saying there were no military targets nearby.

No similar warnings were given for strikes that hit apartment buildings in two other central districts, killing at least 10 people, according ​to Lebanese authorities.

Smoke poured from the balcony of one building as residents swept debris from the street, surrounded by wrecked cars.

While Israel has been striking Hezbollah‑controlled southern suburbs of Beirut for days, the latest attacks were among the worst ‌to hit central ⁠parts of the capital in decades.

Inside Israel, an Iranian missile tore a crater into the pavement and set cars ablaze in a residential area of Holon, just south of Tel Aviv.

“There was an alarm, we went into the shelter, we heard a crazy boom,” resident Leah Palteal told Reuters.

“When we were allowed to come out… We saw fire, we went downstairs, we saw that everything here was blown up.”

Israel has also launched a ground assault in southern Lebanon. It acknowledged on Wednesday that its troops had fired from a tank at a UN base a week into the war, injuring three Ghanaian peacekeepers in what it said was a mistake.

Mounting casualties

Lebanese authorities say 900 people have been killed in ​the country and 800,000 forced to flee their ⁠homes.

US-based Iran human rights group HRANA said on Monday that an estimated 3,000-plus people have been killed in Iran since the US-Israeli attacks began at the end of February.

Iranian attacks have killed people in Iraq and across the Gulf states. Fourteen have been killed in Israel.

The Israel Defence Forces said it struck targets in Tehran on Tuesday that included the headquarters of the Revolutionary Guards’ security unit, and a maintenance centre linked to Iran’s internal security forces.

Iran told the UN nuclear watchdog that a projectile had also hit an area near the Bushehr nuclear power plant ⁠on Tuesday evening, ​but caused no damage or injuries.

IAEA chief Rafael Grossi reiterated his call for maximum restraint.

The United States military said on Tuesday ​it had targeted sites along Iran’s coastline near the Strait of Hormuz with powerful “bunker-buster” bombs, saying Iranian anti-ship missiles there posed a threat to international shipping.

The strait, where a fifth of global oil and liquefied natural gas supplies normally pass within a few miles of Iran’s ​coast, remains largely closed as Iran threatens to attack tankers linked to the US and Israel. Oil prices have surged.