Group D leaders Sporting, meanwhile, made it two wins out of two games with a late 2-0 triumph over Tottenham.

This was Inter’s first victory in the competition’s Group C, after a 2-0 home defeat to Bayern Munich last week.

Dzeko broke the deadlock in the 20th minute with a lovely finish into the far corner. But despite controlling the ball during the first half, the Italians headed to the break with only a narrow lead.

Plzen lost Pavel Bucha at the hour mark due to a red card, making it even more difficult for the home side to gain possession.

It didn’t take long for Inter to hit the net a second time. Following an assist from Dzeko, Denzel Dumfries was clinical to secure the Italians the three points.

In the clash between Sporting and Tottenham, both goalkeepers had a bright evening and the game was set to end in a goalless draw, but Paulinho broke the deadlock in the 90th minute and Arthur Gomes netted a stunner just two minutes later.

Later on Wednesday, Bayern Munich host Barcelona and former striker Robert Lewandowski, while Liverpool seek their first win against Ajax Amsterdam.